Our bodies have a complex lymphatic system

lymphatic system that includes fluid and lymph nodes that help our bodies to work efficiently, and to fight germs. There are hundreds of lymph nodes throughout the body, including in the chest, neck, armpit, groin, pelvis, and along the gut.

There are two main types of lymphocyteslymphocytes, also called white blood cells, in the lymphatic system. These are called:

B cells

B lymphocytes
B lymphocytes

T cells

T lymphocytes
T lymphocytes

A lymphoma is a cancercancer of the lymphatic system.

In lymphomas, healthy lymphocytes transform into cancerous ones and begin to divide out of control. Lymphomas can involve either B cells or T cells and begin and travel almost anywhere in the body

There are two main forms of lymphoma:

Hodgkin lymphomaHodgkin lymphoma and non-Hodgkin lymphomanon-Hodgkin lymphoma.

Mantle cell lymphoma, or MCL, is a rare type of non-Hodgkin lymphoma that involves B cells.

Mantle cell lymphoma accounts for about 5% of all lymphomas.

Mantle cell lymphoma affects mostly men over the age of 60.

The disease is called “mantle cell lymphoma” because the tumor cells originally come from the outer edge of the lymph nodeslymph nodes called the “mantle zone.”

Common signs and symptoms of mantle cell lymphoma may include:

  • Swelling of lymph nodes in the neck, armpit, or groin area
  • Gastrointestinal pain, diarrhea, or bloody stools
  • Fever for no known reason
  • Recurring night sweats
  • Feeling very tired
  • Weight loss for no known reason
  • Skin rash or itchy skin
  • Pain in the chest, abdomen, or bones for no reason

Relapsed MCL

Patients with MCL may respond well to treatment once the disease is diagnosed, but within a few years, the disease may return after treatment. This means patients have relapsed MCL.

Refractory MCL

Patients may also have refractory MCL. Refractory MCL means that the disease does not respond to treatment.


The lymphatic system includes the tissues and organs that make, store, and carry the white blood cells that fight infections and other diseases. These include the bone marrow, spleen, thymus, and lymph nodes, as well as lymphatic vessels that spread throughout the body.

Lymphocytes are a type of white blood cells that are part of the immune system.

B lymphocytes produce antibodies that help fight invading bacteria, viruses, and toxins in the body.

T lymphocytes destroy the body’s own cells that have been taken over by viruses or have developed into cancer.

Cancer is the name for a collection of diseases in which some of the body’s cells begin to divide without stopping and spread into surrounding tissues.

Hodgkin lymphoma is a type of cancer of the immune system marked by the presence of a specific kind of cell called a Reed-Sternberg cell.

Non-Hodgkin lymphoma is a term that describes a large group of different types of lymphocyte cancers. Mantle cell lymphoma is a type of non-Hodgkin lymphoma.

Lymph nodes are small structures in the body that are part of the immune system. Lymph nodes contain lymphocytes that help the body fight infection and diseases.

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CALQUENCE may cause serious side effects, including:

  • Bleeding problems (hemorrhage) may happen during treatment with CALQUENCE, and can be serious. Your risk of bleeding may increase if you are also taking a blood thinner medicine. Tell your healthcare provider if you have any signs or symptoms of bleeding, including:
    • blood in your stools or black stools (looks like tar)
    • pink or brown urine
    • unexpected bleeding, or bleeding that is severe or you cannot control
    • vomit blood or vomit that looks like coffee grounds
    • cough up blood or blood clots
    • dizziness
    • weakness
    • confusion
    • change in your speech
    • headache that lasts a long time
  • Infections. Infections can happen during treatment with CALQUENCE. These infections can be serious and may lead to death. Tell your healthcare provider right away if you have fever, chills, or flu-like symptoms.
  • Decrease in blood cell counts. Decreased blood counts (white blood cells, platelets, and red blood cells) are common with CALQUENCE, but can also be severe. Your healthcare provider should do monthly blood tests to check your blood counts.
  • Second primary cancers. New cancers have happened in people during treatment with CALQUENCE, including cancers of the skin. Use sun protection when you are outside in sunlight.
  • Heart rhythm problems (atrial fibrillation and atrial flutter) have happened in people treated with CALQUENCE. Tell your healthcare provider if you have any of the following signs or symptoms:
    • your heartbeat is fast or irregular
    • feel lightheaded or dizzy
    • pass out (faint)
    • shortness of breath
    • chest discomfort

The most common side effects of CALQUENCE include:

  • headache
  • diarrhea
  • tiredness
  • muscle aches
  • bruising

These are not all the possible side effects of CALQUENCE. Call your doctor for medical advice about side effects.

You may report side effects related to AstraZeneca products by clicking here.


CALQUENCE is a prescription medicine used to treat adults with mantle cell lymphoma (MCL) who have received at least one prior treatment for their cancer.

It is not known if CALQUENCE is safe and effective in children.

Please see complete Prescribing Information including Patient Information.