Our bodies have a complex lymphatic system

lymphatic system that includes fluid and lymph nodes that help our bodies to work efficiently, and to fight germs. There are hundreds of lymph nodes throughout the body, including in the chest, neck, armpit, groin, pelvis, and along the gut.

There are two main types of lymphocyteslymphocytes, also called white blood cells, in the lymphatic system. These are called:

B cells

B lymphocytes
B lymphocytes

T cells

T lymphocytes
T lymphocytes

A lymphoma is a cancercancer of the lymphatic system.

In lymphomas, healthy lymphocytes transform into cancerous ones and begin to divide out of control. Lymphomas can involve either B cells or T cells and begin and travel almost anywhere in the body

There are two main forms of lymphoma:

Hodgkin lymphomaHodgkin lymphoma and non-Hodgkin lymphomanon-Hodgkin lymphoma.

Mantle cell lymphoma, or MCL, is a rare type of non-Hodgkin lymphoma that involves B cells.

Mantle cell lymphoma accounts for about 5% of all lymphomas.

Mantle cell lymphoma affects mostly men over the age of 60.

The disease is called “mantle cell lymphoma” because the tumor cells originally come from the outer edge of the lymph nodeslymph nodes called the “mantle zone.”

Common signs and symptoms of mantle cell lymphoma may include:

  • Swelling of lymph nodes in the neck, armpit, or groin area
  • Gastrointestinal pain, diarrhea, or bloody stools
  • Fever for no known reason
  • Recurring night sweats
  • Feeling very tired
  • Weight loss for no known reason
  • Skin rash or itchy skin
  • Pain in the chest, abdomen, or bones for no reason

Relapsed MCL

Patients with MCL may respond well to treatment once the disease is diagnosed, but within a few years, the disease may return after treatment. This means patients have relapsed MCL.

Refractory MCL

Patients may also have refractory MCL. Refractory MCL means that the disease does not respond to treatment.


The lymphatic system includes the tissues and organs that make, store, and carry the white blood cells that fight infections and other diseases. These include the bone marrow, spleen, thymus, and lymph nodes, as well as lymphatic vessels that spread throughout the body.

Lymphocytes are a type of white blood cells that are part of the immune system.

B lymphocytes produce antibodies that help fight invading bacteria, viruses, and toxins in the body.

T lymphocytes destroy the body’s own cells that have been taken over by viruses or have developed into cancer.

Cancer is the name for a collection of diseases in which some of the body’s cells begin to divide without stopping and spread into surrounding tissues.

Hodgkin lymphoma is a type of cancer of the immune system marked by the presence of a specific kind of cell called a Reed-Sternberg cell.

Non-Hodgkin lymphoma is a term that describes a large group of different types of lymphocyte cancers. Mantle cell lymphoma is a type of non-Hodgkin lymphoma.

Lymph nodes are small structures in the body that are part of the immune system. Lymph nodes contain lymphocytes that help the body fight infection and diseases.

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Important Safety Information About CALQUENCE® (acalabrutinib) capsules

Before taking CALQUENCE, tell your healthcare provider about all of your medical conditions, including if you:

  • have had recent surgery or plan to have surgery. Your healthcare provider may stop CALQUENCE for any planned medical, surgical, or dental procedure.
  • have bleeding problems.
  • have or had heart rhythm problems.
  • have an infection.
  • have or had liver problems, including hepatitis B virus (HBV) infection.
  • are pregnant or plan to become pregnant. CALQUENCE may harm your unborn baby and cause problems during childbirth (dystocia).
    • If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with CALQUENCE
    • Females who are able to become pregnant should use effective birth control (contraception) during treatment with CALQUENCE and for at least 1 week after the last dose of CALQUENCE
  • are breastfeeding or plan to breastfeed. It is not known if CALQUENCE passes into your breast milk. Do not breastfeed during treatment with CALQUENCE and for at least 2 weeks after your final dose of CALQUENCE.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-­counter medicines, vitamins, and herbal supplements. Taking CALQUENCE with certain other medications may affect how CALQUENCE works and can cause side effects. Especially tell your healthcare provider if you take a blood thinner medicine.

How should I take CALQUENCE?

  • Take CALQUENCE exactly as your healthcare provider tells you to take it.
  • Do not change your dose or stop taking CALQUENCE unless your healthcare provider tells you to.
  • Your healthcare provider may tell you to decrease your dose, temporarily stop, or completely stop taking CALQUENCE if you develop certain side effects.
  • Take CALQUENCE 2 times a day (about 12 hours apart).
  • Take CALQUENCE with or without food.
  • Swallow CALQUENCE capsules whole with a glass of water. Do not open, break, or chew capsules.
  • If you need to take an antacid medicine, take it either 2 hours before or 2 hours after you take CALQUENCE.
  • If you need to take certain other medicines called acid reducers (H2-receptor blockers), take CALQUENCE 2 hours before the acid reducer medicine.
  • If you miss a dose of CALQUENCE, take it as soon as you remember. If it is more than 3 hours past your usual dosing time, skip the missed dose and take your next dose of CALQUENCE at your regularly scheduled time. Do not take an extra dose to make up for a missed dose.

What are the possible side effects of CALQUENCE?

CALQUENCE may cause serious side effects, including:

  • Serious infections can happen during treatment with CALQUENCE and may lead to death. Your healthcare provider may prescribe certain medicines if you have an increased risk of getting infections. Tell your healthcare provider right away if you have any signs or symptoms of an infection, including fever, chills, or flu-like symptoms.
  • Bleeding problems (hemorrhage) can happen during treatment with CALQUENCE and can be serious and may lead to death. Your risk of bleeding may increase if you are also taking a blood thinner medicine. Tell your healthcare provider if you have any signs or symptoms of bleeding, including blood in your stools or black stools (looks like tar), pink or brown urine, unexpected bleeding or bleeding that is severe or you cannot control, vomit blood or vomit that looks like coffee grounds, cough up blood or blood clots, dizziness, weakness, confusion, changes in your speech, headache that lasts a long time, or bruising or red or purple skin marks
  • Decrease in blood cell counts. Decreased blood counts (white blood cells, platelets, and red blood cells) are common with CALQUENCE, but can also be severe. Your healthcare provider should do blood tests to check your blood counts regularly during treatment with CALQUENCE.
  • Second primary cancers. New cancers have happened in people during treatment with CALQUENCE, including cancers of the skin or other organs. Your healthcare provider will check you for skin cancers during treatment with CALQUENCE. Use sun protection when you are outside in sunlight.
  • Heart rhythm problems (atrial fibrillation and atrial flutter) have happened in people treated with CALQUENCE. Tell your healthcare provider if you have any of the following signs or symptoms: fast or irregular heartbeat, dizziness, feeling faint, chest discomfort, or shortness of breath

The most common side effects of CALQUENCE include headache, diarrhea, muscle and joint pain, upper respiratory tract infection, and bruising.

These are not all the possible side effects of CALQUENCE. Call your doctor for medical advice about side effects.

You may report side effects related to AstraZeneca products by clicking here.


CALQUENCE is a prescription medicine used to treat adults with mantle cell lymphoma (MCL) who have received at least one prior treatment for their cancer.

It is not known if CALQUENCE is safe and effective in children.

Please see complete Prescribing Information including Patient Information.