For people with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL)

Financial Support

You may be able to pay as little as

^$0*

per month

^*Terms and conditions apply. See site for full eligibility and terms of use.

Not an actual patient.

^*Terms and conditions apply. See site for full eligibility and terms of use.

The CALQUENCE Copay Savings Program can help eligible, commercially insured patients with their out-of-pocket costs.

There are no income requirements to participate in the program. Talk to your doctor or pharmacist, who can help you enroll in the program and file claims on your behalf. For more information and eligibility requirements, visit AstraZenecaSpecialtySavings.com or call AstraZeneca Access 360™ at 1-844-ASK-A360 (1-844-275-2360).

CALQUENCE is covered by most commercial plans

CALQUENCE is covered for

Enter your ZIP code to find coverage in your area.

For government-insured or uninsured patients

Independent foundation assistance

There may be other means of financial assistance. While not associated with AstraZeneca, assistance may be available through independent foundations, which can provide a variety of resources and support, including copay assistance, transportation, patient education, and more. To explore these resources,
visit www.astrazeneca-us.com/medicines/affordabilitywww.astrazeneca-us.com/medicines/
affordability.

Financial support by independent foundations is not guaranteed. Each foundation sets its own eligibility requirements and support determinations. Your healthcare provider can help you apply for foundation support.

ASTRAZENECA ACCESS 360^TM PERSONAL SUPPORT AFTER YOU AND YOUR DOCTOR DECIDE TO START TREATMENT

If your doctor has prescribed CALQUENCE, you may have questions. The AstraZeneca Access 360^TM program can answer your questions about:

Insurance coverage
Out-of-pocket costs
Patient assistance programs

To learn more about the AstraZeneca Access 360^TM program, please call 1-844-ASK-A360 (1-844-275-2360), Monday through Friday, 8 AM – 6 PM ET or
visit www.MyAccess360.com.

AZ&ME PRESCRIPTION SAVINGS PROGRAM

AZ&ME provides AstraZeneca medicines at no cost to qualifying people. For more information, call 1-800-AZandMe (1-800-292-6363) or visit www.AZandMeApp.com.

For Medicare Part D patients

For the First-Line Treatment of CLL, CALQUENCE is the Sole BTKi on the VA National Formulary.

Learn more about the 2026 Medicare Part D Reform updates.
Visit www.azmedicareupdates.com/

CALQUENCE is recommended for new patients with CLL/SLL on the VA National Formulary.^†

^†This coverage determination applies to health plans associated with the Department of Veterans Affairs, Indian Health Service, Bureau of Prisons, Option 2 State Veterans Homes, and Federal Health Care Center.

BTKi=Bruton tyrosine kinase inhibitor.

Important Safety Information About CALQUENCE^® (acalabrutinib)

Before taking CALQUENCE, tell your healthcare provider about all of your medical conditions, including if you:

have had recent surgery or plan to have surgery. Your healthcare provider may stop CALQUENCE for any planned medical, surgical, or dental procedure.
have bleeding problems.
have or had heart rhythm problems.
have an infection.
have or had liver problems, including hepatitis B virus (HBV) infection.
are pregnant or plan to become pregnant. CALQUENCE may harm your unborn baby and cause problems during childbirth (dystocia).
Females who are able to become pregnant:
- Your healthcare provider may do a pregnancy test before you start treatment with CALQUENCE
- Use effective birth control (contraception) during treatment with CALQUENCE and for 1 week after the last dose of CALQUENCE
are breastfeeding or plan to breastfeed. It is not known if CALQUENCE passes into your breast milk. Do not breastfeed during treatment with CALQUENCE and for 2 weeks after your last dose of CALQUENCE.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking CALQUENCE with certain other medications may affect how CALQUENCE works and can cause side effects. Especially tell your healthcare provider if you take a blood thinner medicine.

How should I take CALQUENCE?

Take CALQUENCE exactly as your healthcare provider tells you to take it.
Do not change your dose or stop taking CALQUENCE unless your healthcare provider tells you to.
Your healthcare provider may tell you to decrease your dose, temporarily stop, or completely stop taking CALQUENCE if you develop certain side effects.
Take CALQUENCE 2 times a day (about 12 hours apart).
Take CALQUENCE with or without food.
Swallow CALQUENCE tablets whole with a glass of water. Do not chew, crush, dissolve, or cut tablets.
If you miss a dose of CALQUENCE, take it as soon as you remember. If it is more than 3 hours past your usual dosing time, skip the missed dose and take your next dose of CALQUENCE at your regularly scheduled time. Do not take an extra dose to make up for a missed dose.

What are the possible side effects of CALQUENCE?

CALQUENCE can cause serious side effects, including:

Serious infections have happened during treatment with CALQUENCE and may lead to death. Your healthcare provider may prescribe certain medicines if you have an increased risk of getting infections. Tell your healthcare provider right away if you have any signs or symptoms of an infection, including fever, chills, or flu-like symptoms.
Bleeding problems (hemorrhage) have happened in people treated with CALQUENCE and can be serious and may lead to death. Your risk of bleeding may increase if you are also taking a blood thinner medicine. Tell your healthcare provider right away if you have any signs or symptoms of bleeding, including blood in your stools or black stools (looks like tar), pink or brown urine, unexpected bleeding or bleeding that is severe or you cannot control, vomit blood or vomit that looks like coffee grounds, cough up blood or blood clots, dizziness, weakness, confusion, changes in your speech, headache that lasts a long time, or bruising or red or purple skin marks.
Decrease in blood cell counts. Decreased white blood cell counts, red blood cell counts, and platelet counts can be severe during treatment with CALQUENCE. Your healthcare provider should do blood tests to check your blood counts regularly during treatment with CALQUENCE.
Second primary cancers. New cancers have happened in people during treatment with CALQUENCE, including cancers of the skin or other organs. Your healthcare provider will check you for skin cancers during treatment with CALQUENCE. Use sun protection when you are outside in sunlight.
Heart rhythm problems (cardiac arrhythmias) have happened in people treated with CALQUENCE, and can be serious or lead to death. Tell your healthcare provider right away if you have any of the following signs or symptoms: fast or irregular heartbeat, dizziness, feeling faint, chest discomfort, or shortness of breath.
Liver problems. Liver problems have happened in people treated with CALQUENCE, and can be severe or life-threatening, or lead to death. Tell your healthcare provider right away if you experience stomach pain or discomfort, urine of dark color or yellowing of your skin. Your healthcare provider will request tests to monitor your liver function during treatment with CALQUENCE.

The most common side effects of CALQUENCE include upper respiratory infection, diarrhea, headache, muscle and joint pain, decreased white blood cell counts, and decreased platelet counts.

These are not all the possible side effects of CALQUENCE. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is CALQUENCE?

CALQUENCE is a prescription medicine used to treat adults with:

Mantle cell lymphoma (MCL) in combination with bendamustine and rituximab in people who have not had prior treatment for MCL and who cannot receive a type of stem cell transplant that uses their own blood stem cells (autologous hematopoietic stem cell transplantation [HSCT]).
Mantle cell lymphoma (MCL) who have received at least one prior therapy.
Chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).

It is not known if CALQUENCE is safe and effective in children.

Please see full Prescribing Information, including Patient Information .

You may report side effects related to AstraZeneca
products.